The present work examined the functional constituents, antioxidant and anti-inﬂammatory activities of Greek Thymus vulgaris (TV) oil and water extracts. Also, the possible synergism between Egyptian Chlorella vulgaris ethanolic extract (CVE) and TV oil or water extracts was evaluated. The phytochemicals, total antioxidant capacity, reducing power, antiradical, and anti-lipid peroxidation abilities of the extracts were evaluated. Also, this study measured the ability of the extracts to detoxify the LPS-induced inﬂammation and oxidative stress in vitro. The extracts showed high phenolic and triterpenoid content. The combined extracts displayed higher antioxidant eﬀects than individual extracts. The anti-inﬂammatory assay indicated a potent synergistic eﬀect of the tested combinations. Since they attenuated the LPS-induced elevation in the nuclear factor-kappa (NF-к) B, inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase (COX)-2, tumour necrosis factor (TNF)-α, NO and oxidative stress. Thus, Greek TV extracts have antioxidant and anti-inﬂammatory activities, which can be potentiated by mixing with CVE.