Research
The Hydroalcoholic Extract of Uncaria tomentosa (Cat’s Claw)Inhibits the Infection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) In Vitro
-e coronavirus disease 2019 (COVID-19) has become a serious problem for public health since it was identified in theprovince of Wuhan (China) and spread around the world producing high mortality rates and economic losses. Nowadays, theWHO recognizes traditional,...
Uncaria tomentosa (cat’s claw): a promising herbalmedicine against SARS-CoV-2/ACE-2 junction andSARS-CoV-2 spike protein based on molecularmodeling
COVID-19 is a novel severe acute respiratory syndrome coronavirus. Currently, there is no effectivetreatment and vaccines seem to be the solution in the future. Virtual screening of potential drugsagainst the S protein of severe acute respiratory syndrome corona virus...
Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review
The whole world is entangled by the coronavirus disease (COVID-19) pandemic causedby severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), people aredying in thousands each day, and without an actual medication, it seems not possiblefor the bringing this...
Identification of phytocompounds from Houttuynia cordataThunb. as potential inhibitors for SARS‑CoV‑2 replication proteinsthrough GC–MS/LC–MS characterization, molecular docking and molecular dynamics simulation
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a massive viraldisease outbreak of international concerns. The present study is mainly intended to identify the bioactive phytocompoundsfrom traditional antiviral herb...
Autohydrolysis of Lentinus edodes for ObtainingExtracts with Antiradical Properties
The autohydrolysis of Lentinus edodes was proposed for the extraction of components withantioxidant properties. Operation under non-isothermal conditions was evaluated and comparedwith isothermal heating. The influence of process severity was assessed in the range of...
In Vitro Anti-proliferative and Anti-invasive Effect ofPolysaccharide-rich Extracts from Trametes Versicolorand Grifola Frondosa in Colon Cancer Cells
Colorectal cancer (CRC) is one of leading cause of mortality in western countries and noveltreatment strategies are required. The medicinal application of mushrooms has been used intraditional medicine in many oriental countries. Polysaccharide-rich extracts obtained...
Potential use of polyphenols in the battle against COVID-19
The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection has stressed the urgent need to find a potent drug. Although repurposing of known drugs currently provides...
Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency
The human intestine contains an intricate ecological community of dwelling bacteria, referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, antibiotics, as...
Cholesterol-Lowering Activity of the Major Polyphenols in
Grape Seed
The major polyphenols in grape seed have been shown to have beneficial health effects in the prevention of dyslipidemia and cardiovascular diseases. In this present study, we investigated the cholesterol-lowering activity of three major polyphenolic compounds found in...
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Numerous studies have demonstrated the importance of naturally occurring dietary polyphenols in promoting cardiovascular health and emphasized the significant role these compounds play in limiting the effects of cellular aging. Polyphenols such as resveratrol,...
Quercetin with the potential effect on allergic diseases
Quercetin is a naturally occurring polyphenol favonoid which is rich in antioxidants. It has anti-allergic functions thatare known for inhibiting histamine production and pro-infammatory mediators. Quercetin can regulate the Th1/Th2 stability, and decrease the...
GlucoMedix®- An Extract of Stevia rebaudiana and Uncaria tomentosa Reduces Hyperglycemia, Hyperlipidemia, and Hypertension in Rat Models Without Toxicity
The Examiner of Alternative MedicineThursday, August 11, 2022 By León F. Villegas Vílchez,1,2 Julio Hidalgo Ascencios,2 and Thomas P. Dooley3 This article is reprinted with the consent of the authors as a redacted summary of the following: León F....
Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients
Abstract Background GlucoMedix® is an all-natural phytotherapy consisting of a hydro-alcoholic extract of Stevia rebaudiana (Bertoni) Bertoni and pentacyclic chemotype Uncaria tomentosa (Willd. Ex Schult.) DC. The nutraceutical product has...
GlucoMedix ®, an Extract of Stevia Rebaudiana and UncariaTomentosa, Reduces Hyperglycemia, Hyperlipidemia, and Hypertension in Rat Models Without Toxicity: A Treatment For Metabolic Syndrome
Abstract Background: The objective of this in vivo study is to evaluate in five rat models the pharmacologic effects and toxicity of a commercial hydro-alcoholic extract, GlucoMedix®, derived from Stevia rebaudiana and the pentacyclic...